Table 1

Pharmacokinetic parameters of [3H]TCA and DBSP

TCADBSP
MaleFemaleMaleFemale
CLtot(ml/h/kg)1-a 40.8  ± 1.646.6  ± 0.730.4  ± 1.529.6  ± 1.4
CLurine,p(ml/h/kg)1-b 0.0382  ± 0.00530.168  ± 0.0170.0126  ± 0.00120.0965  ± 0.0124
f u 0.0595  ± 0.00210.0553  ± 0.01920.00540  ± 0.000430.00502  ± 0.00070
R b 0.577  ± 0.0410.593  ± 0.0430.708  ± 0.0400.700  ± 0.059

Data shown in Fig. 1 were used to determine these parameters (mean ± S.E. of three or four rats). Rats received an intravenous bolus injection of [3H]TCA (5 μCi/kg) or DBSP (2 mg/kg).

  • 1-a  The total clearance obtained by dividing the dose by the AUC.

  • 1-b  The urinary clearance based on the plasma concentration (CLurine,p) obtained by dividing the cumulative urinary excretion by the AUC.