Table 2

Effects of THC on the percentage of splenic subsets in vivo

Cellularity2-aSplenocyte Populations2-c
CD3+CD4+CD8+CD19+Mac-3+
cell no. × 106/spleen
DMSO91.20  ± 2.22-b 45.20  ± 4.3423.45  ± 0.5618.05  ± 3.1847.95  ± 6.1116.50  ± 1.82
(41.13)(21.34)(16.43)(43.63)(15.02)
THC45.12  ± 2.047.30  ± 5.9626.45  ± 5.3019.80  ± 2.7347.45  ± 0.3017.60  ± 0.10
(21.29)(11.90) (8.91)(21.35) (7.92)
  • 2-a  C57BL/6 mice were treated with THC (10 mg/kg body weight) or the vehicle. One day after treatment with THC, the spleens were harvested, and the total cellularity was determined.

  • 2-b  Data represent mean ± S.E.M. obtained from six mice.

  • 2-c  The percentage of each splenocyte subset was determined using flow cytometry. The data represent mean ± S.E.M. of percentage of lymphocyte and macrophage subsets in the spleens obtained from six mice. The numbers in parentheses represent the mean total cellularity × 106 of each cell population found in the spleens.