Table 1

Effects of THC on the percentage of thymic subsets in vivo

Cellularity1-aT-Cell Subsets1-c
CD4CD8CD4+ CD8+CD4+CD8CD4 CD8+
cell no. × 106/thymus
Vehicle182  ± 121-b 4.13  ± 0.0980.92  ± 0.8710.77  ± 1.214.18  ± 0.29
(7.52)(147.27)(19.60)(7.61)
THC98  ± 134.80  ± 0.7979.63  ± 4.2110.50  ± 4.505.10  ± 1.21
(4.70) (78.04)(10.29)(4.99)
  • 1-a  C57BL/6 mice were treated with THC (10 mg/kg body weight) or the vehicle. One day after treatment with THC, the thymocytes were harvested, and the total cellularity was determined.

  • 1-b  Data represent mean ± S.E.M. obtained from six mice.

  • 1-c  T-cell subsets were determined using flow cytometry. The data represent mean ± S.E.M. of the percentage of T-cell subsets in the thymus obtained from six mice. The numbers in parentheses represent the mean total cellularity × 106 of each T-cell subset found in the thymi.