Table 1

Kinetic parameters for nicotine uptake by Caco-2 cells

	Apical Side		Basolateral Side
	K_m	V_max	K_m	V_max
	mM	nmol/mg protein/15 s	mM	nmol/mg protein/15 s
Control	0.91 ± 0.14	2.72 ± 0.35	0.84 ± 0.20	1.53 ± 0.42
⁺Diphenhydramine	0.98 ± 0.25	0.69 ± 0.29^1-150	0.80 ± 0.17	0.49 ± 0.28^1-150

Each value represents the mean ± S.E. of 11 monolayers from four separate experiments.

↵1-150 P < 0.05, significantly different from controls.