Table 4

Frequencies of the exon 5 3375C>T allele (Arg257Cys) in major ethnic groups

Group	n	T/T	C/T	C/C	Frequency of T Allele
					%
White	52	0	2	50	1.9^4-a
Black	52	1	13	38	14.4
Hispanic	52	0	6	46	5.8^4-b
Asian	52	0	8	44	7.7

One-half (104) of the samples were analyzed by PCR-SSCP, whereas the other half were genotyped by PCR-RFLP as described underExperimental Procedures. Results from males and females were not significantly different.

↵4-a The frequency in white people was significantly lower than in black people (χ² = 10.8,P = 0.001).
↵4-b The frequency in Hispanic people was significantly lower than in black people (χ² = 4.29,P = 0.038).