Mean ± S.D. pharmacokinetic parameters of RESAGL and RESGLU following oral administration of 50 mg/kg to intact rats (n = 6)
| RESAGL | RESGLU | |
|---|---|---|
| AUC0– t(μmol·h/l) | 7.0 ± 2.0 | 321.9 ± 56.9 |
| AUCinf (μmol·h/l) | 7.1 ± 2.0 | 324.7 ± 57.6 |
| C max(μmol/l) | 6.57 ± 1.55 | 105.2 ± 32.4 |
| T max (h) | 0.29 ± 0.10 | 0.42 ± 0.30 |
| T 1/2TER (h) | 1.48 ± 0.44 | 1.55 ± 0.42 |
| CL/F (l/h/kg) | 32.4 ± 7.5 | N.A. |
| V area/F(l/kg) | 71.9 ± 32.0 | N.A. |
| F (%) | 38.1 ± 13.5 | N.A. |
| CL/Fm (l/h/kg) | N.A. | 0.70 ± 0.15 |
| Varea/Fm (l/kg) | N.A. | 1.57 ± 0.62 |
N.A., not applicable.