Table 1

Pharmacokinetic parameters after oral administration of SV (4 mg/kg) to dogs pretreated with vehicle or GFZ (75 mg/kg p.o.) twice daily for 5 days

Compound MeasuredVehicle PhaseGFZ PhaseRatio (Range) GFZ/Vehicle
AUC0–12hCmaxTmaxAUC0–12hCmaxTmaxAUCCmax
ng/ml · h ng/ml h ng/ml · h ng/ml h
SV136  ± 5447.5  ± 260.8  ± 0.366  ± 161-a 11.3  ± 3.91-b 3.0  ± 1.01-b 0.6  ± 0.30.3  ± 0.2
(0.3–1.0)
SVA108  ± 6343.8  ± 261.0  ± 0.4288  ± 1081-a 80.8  ± 17 1-a 3.0  ± 0.71-b 3.8  ± 3.22.6  ± 2.0
(1.0–9.3)
Total inhibitor1008  ± 454328  ± 1781.1  ± 0.21372  ± 355338  ± 753.2  ± 0.41-b 1.6  ± 1.01.4  ± 0.9
(0.5–3.1)
Active inhibitor534  ± 258182  ± 1021.2  ± 0.31066  ± 3421-a 289  ± 583.2  ± 0.41-b 2.2  ± 1.62.0  ± 1.3
(0.7–4.8)

Results represent means ± S.D., n = 5.

  • 1-a  Statistically significant difference from control (p < 0.08).

  • 1-b  Statistically significant difference from control (p < 0.05).