Table 5

Binding parameters of 11 drugs in plasma and human liver microsomes

Compound	f_u Plasma	f_{u inc}	f_u plasma/f_{u inc}
Codeine^5-a	0.93	0.89 ± 0.19	1.04
Ethinylestradiol^5-a	0.03	0.32 ± 0.23	0.09
Furosemide^5-b	0.03	0.94 ± 0.06	0.03
Gemfibrozil^5-a	0.03	0.59 ± 0.22	0.05
Imipramine^5-b	0.11	0.13 ± 0.04	0.85
Ketoprofen^5-a	0.06	0.91 ± 0.15	0.07
Morphine^5-b	0.65	0.8 ± 0.17	0.81
Naloxone^5-b	0.62	0.81 ± 0.21	0.77
Naproxen^5-a	0.01	0.61 ± 0.01	0.02
Propofol^5-b	0.02	0.05 ± 0.04	0.4
Valproic acid^5-a	0.1	1	0.1

f_u plasma values were obtained from Holfard (1998) andCockshott et al. (1992). f_{u inc} are mean ± S.D. determined using three separate equilibrium dialysis experiments, each performed in duplicate at 2 mg/ml protein concentration.

↵5-a Basic/neutral drug.
↵5-b Acidic drug.