Human total in vivo clearance and clearance due to glucuronidation for 11 drugs studied
| Compound | In vivo CL | % Gluc | In vivo Gluc | References |
|---|---|---|---|---|
| ml/min/kg | ml/min/kg | |||
| Codeine | 10.7 | 70 | 7.49 | Bertz and Granneman (1997), Vozeh (1988) |
| Ethinylestradiol | 5.4 | 35 | 1.89 | Chiou et al. (1998), Vozeh (1988), Maggs et al. (1983) |
| Furosemide | 1.9 | 14 | 0.27 | Vozeh (1988), Hammarlund and Benet (1989) |
| Gemfibrozil | 1.69 | 40 | 0.68 | Bertz and Granneman (1997) |
| Imipramine | 15, 13.8 | 10 | 1.44 | Chiou et al. (1998), Vozeh (1988) |
| Ketoprofen | 1.2 | 90 | 1.08 | Chiou et al. (1998), Vozeh (1988) |
| Morphine | 24, 17.1 | 90 | 18.5 | Chiou et al. (1998), Vozeh (1988) |
| Naloxone | 25, 24.8 | 65 | 16.2 | Schneider et al. (1999), Bertz and Granneman (1997), Vozeh (1988) |
| Naproxen | 0.07 | 57 | 0.04 | Vozeh (1988), Vree et al. (1993) |
| Propofol | 27.1, 24.8 | 53 | 14.4 | Simons et al. (1988), Vozeh (1988) |
| Valproic acid | 0.12 | 60 | 0.07 | Chiou et al. (1998), Vozeh (1988) |
Gluc, glucuronidation.