Table 2

Human physiological and biochemical parameters important in scaling in vitro pharmacokinetic data

Human liver weight20g/kg body of weight
Liver microsome protein yield45mg/g liver
Liver blood flow20ml/min/kg
Hepatocellularity120106cells/g liver
Kidney weight4.4g/kg body of weight
Kidney microsome protein yield45mg/g kidney
Kidney blood flow18ml/min/kg
Intestine weight30g/kg body of weight
Intestine microsome protein yield3mg/g
Mucosal blood flow4.6ml/min/kg

Parameters obtained from Davies and Morris (1993), Obach et al. (1997), and Lin et al. (1999).