Human physiological and biochemical parameters important in scaling in vitro pharmacokinetic data
| Parameter | Value | Unit |
|---|---|---|
| Human liver weight | 20 | g/kg body of weight |
| Liver microsome protein yield | 45 | mg/g liver |
| Liver blood flow | 20 | ml/min/kg |
| Hepatocellularity | 120 | 106cells/g liver |
| Kidney weight | 4.4 | g/kg body of weight |
| Kidney microsome protein yield | 45 | mg/g kidney |
| Kidney blood flow | 18 | ml/min/kg |
| Intestine weight | 30 | g/kg body of weight |
| Intestine microsome protein yield | 3 | mg/g |
| Mucosal blood flow | 4.6 | ml/min/kg |
Parameters obtained from Davies and Morris (1993), Obach et al. (1997), and Lin et al. (1999).