Effects of SSR125543A, antalarmin, and diazepam in the elevated plus-maze test in rats
| Compound | Dose | Time Open Arms | Entries Open Arms | Head-Dips | Attempts | Total Arm Entries |
|---|---|---|---|---|---|---|
| mg/kg p.o. | % | % | ||||
| SSR125543A | 0 | 10.5 ± 2.5 | 22.1 ± 4.3 | 14.9 ± 2.1 | 7.4 ± 0.6 | 10.7 ± 1.0 |
| 3 | 13.3 ± 3.5 | 23.2 ± 5.3 | 19.9 ± 3.2 | 6.2 ± 0.52-150 | 11.1 ± 0.9 | |
| 10 | 25.3 ± 4.5 | 44.7 ± 6.0 | 26.1 ± 2.7 | 4.9 ± 0.42-150 | 12.1 ± 0.6 | |
| 30 | 17.2 ± 3.7 | 33.7 ± 6.2 | 19.2 ± 2.6 | 5.4 ± 0.42-150 | 12.4 ± 1.0 | |
| Antalarmin | 0 | 13.4 ± 1.6 | 32.7 ± 2.9 | 12.1 ± 2.2 | 8.0 ± 0.5 | 11.7 ± 1.4 |
| 3 | 14.6 ± 5.6 | 27.3 ± 8.1 | 12.9 ± 2.9 | 7.9 ± 0.6 | 11.9 ± 1.0 | |
| 10 | 24.1 ± 3.9 | 43.3 ± 5.9 | 29.4 ± 4.32-150 | 6.3 ± 1.1 | 14.3 ± 0.6 | |
| 30 | 30.9 ± 5.22-150 | 47.3 ± 3.1 | 26.3 ± 3.12-150 | 5.9 ± 1.0 | 12.3 ± 1.1 | |
| Diazepam | 0 | 12.4 ± 2.0 | 30.1 ± 3.1 | 17.9 ± 3.0 | 7.5 ± 0.6 | 11.4 ± 0.8 |
| 1 | 16.5 ± 4.8 | 30.8 ± 7.5 | 16.6 ± 3.5 | 7.5 ± 0.8 | 13.3 ± 1.5 | |
| 3 | 32.9 ± 6.32-150 | 45.4 ± 7.5 | 26.4 ± 3.9 | 4.1 ± 0.62-150 | 14.1 ± 1.1 | |
| 10 | 49.1 ± 7.22-150 | 63.0 ± 6.02-150 | 43.4 ± 5.52-150 | 1.4 ± 0.32-150 | 12.6 ± 1.6 |
Data represent mean ± S.E.M. n = 7 to 14.
↵2-150 P < 0.05 (Dunnett's ttest).