Effects of chronic variable stress and venlafaxine treatment on HPA axis
| Saline | Saline +Stress | Venlafaxine | Venlafaxine + Stress | |
|---|---|---|---|---|
| ACTH | 30.3 ± 6.3 (11) | 21.2 ± 3.0 (12) | 25.7 ± 6.1 (12) | 16.8 ± 2.9 (11) |
| Corticosterone | 8.7 ± 2.8 (11) | 10.2 ± 3.8 (12) | 14.0 ± 3.6 (13) | 13.4 ± 3.8 (12) |
| Adrenal weight | 46.5 ± 3.3 (12) | 57.5 ± 2.8 (12)7-150 | 51.1 ± 1.5 (12) | 55.7 ± 2.5 (12) |
Mean ± S.E.M. (n) plasma ACTH concentration (pg/ml), serum corticosterone concentration (ng/ml), and adrenal weight (mg) of rats that received 26-day venlafaxine (30 mg/kg/day) or saline, ± 2-week variable stress.
↵7-150 P < 0.05, chronic stress effect, two-way ANOVA.