Table 6

Effect of acute stress on plasma ACTH and corticosterone concentrations in antidepressant-pretreated rats

Stressor/Treatment GroupACTHPoststress ACTHCorticosteronePoststress Corticosterone
pg/ml ng/ml
30-min Immobilization
 Saline22  ± 6 (6)308  ± 53 (6)21  ± 7 (6)471  ± 26 (6)
 Venlafaxine12  ± 1 (6)258  ± 52 (6)25  ± 8 (6)426  ± 24 (6)
15-min Swim
 Saline28  ± 10 (6)351  ± 28 (7)23  ± 6 (6)328  ± 12 (7)
 Fluoxetine30  ± 4 (6)446  ± 52 (7)17  ± 6 (6)383  ± 19 (7)
 Reboxetine26  ± 6 (6)402  ± 22 (6)9  ± 2 (6)380  ± 13 (6)
 Venlafaxine27  ± 8 (6)365  ± 48 (7)28  ± 13 (6)379  ± 20 (7)
 Tranylcypromine37  ± 11 (6)284  ± 50 (7)26  ± 12 (6)395  ± 35 (7)

Rats were pretreated for 26 to 27 days with the indicated antidepressant agents or saline (doses, see Fig. 2 and Table 1legends). Plasma ACTH and corticosterone were determined from trunk blood collected immediately after the indicated acute stressors or from unstressed rats. Results are given as mean ± S.E.M. (n).