Table 4

CRF1 and CRF2A receptor mRNA expression after venlafaxine treatment and/or chronic variable stress

Brain RegionSalineSaline + StressVenlafaxineVenlafaxine +Stress
CRF1 mRNA
 Paraventricular nucleus100  ± 20 (7)82  ± 19 (7)113  ± 21 (7)80  ± 18 (6)
 Frontal cortex100  ± 9 (7)81  ± 3 (7)88  ± 4 (7)89  ± 4 (6)
 Basolateral amygdala100  ± 7 (6)93  ± 8 (7)90  ± 6 (7)89  ± 4 (8)
CRF2A mRNA
 Lateral septum100  ± 27 (7)108  ± 18 (4)117  ± 14 (5)100  ± 16 (6)
 Ventromedial hypothalamus100  ± 7 (7)101  ± 9 (4)107  ± 14 (6)114  ± 23 (6)

Rats received 26-day venlafaxine (30 mg/kg/day) or saline treatment and received either no stress or chronic variable stress during the last 2 weeks. CRF1 and CRF2A receptor mRNA expression were determined in the indicated regions by in situ hybridization histochemistry. Results are given as mean percentage of control ± S.E.M. (n).