Effects of chronic stress and venlafaxine treatment on CRF concentration
| Region | Saline | Saline + Stress | Venlafaxine | Venlafaxine +Stress |
|---|---|---|---|---|
| Median Eminence | 100 ± 5 (11) | 78 ± 9 (12)3-150 | 87 ± 7 (13) | 64 ± 15 (12) |
| Amygdala | 100 ± 11 (10) | 134 ± 8 (11) | 141 ± 7 (11)3-150 | 140 ± 7 (12) |
| Locus Coeruleus | 100 ± 8 (6) | 58 ± 9 (6)3-150 | 102 ± 16 (6) | 85 ± 11 (6) |
Mean ± S.E.M. (n) of radioimmunoassayed CRF from median eminence and left amygdala (percentage of control: median eminence, 1.95 ng/dissection; amygdala, 107 pg/mg of protein; locus coeruleus, 569 pg/mg of protein). Rats were treated for 26 days with saline or venlafaxine (30 mg/kg/day), and received either no stress or chronic variable stress during the last 2 weeks.
↵3-150 P < 0.05, two-way ANOVA: effect of stress in the median eminence and locus coeruleus, effect of venlafaxine in the amygdala.