Table 1

PVN CRF hnRNA response to 15-min swim stress: effect of chronic antidepressant pretreatment

Drug PretreatmentUnstressedPost-swim Stress
Saline35  ± 3 (5)211  ± 18 (10)
Reboxetine37  ± 2 (6)160  ± 18 (6)
Fluoxetine38  ± 4 (5)178  ± 19 (7)
Venlafaxine37  ± 4 (6)149  ± 16 (7)1-150
Tranylcypromine35  ± 4 (6)131  ± 27 (7)1-150

Rats were pretreated for 26 days with saline, venlafaxine (25 mg/kg/day), reboxetine (6.5 mg/kg/day), fluoxetine (4 mg/kg/day in 12% DMSO), or tranylcypromine (1.85 mg/kg/day). CRF hnRNA expression in the PVN was determined by in situ hybridization histochemistry; results are given as mean ± S.E.M. (n).

  • 1-150P < 0.05, one-way ANOVA between stress groups, Dunnett's post test.