PVN CRF hnRNA response to 15-min swim stress: effect of chronic antidepressant pretreatment
| Drug Pretreatment | Unstressed | Post-swim Stress |
|---|---|---|
| Saline | 35 ± 3 (5) | 211 ± 18 (10) |
| Reboxetine | 37 ± 2 (6) | 160 ± 18 (6) |
| Fluoxetine | 38 ± 4 (5) | 178 ± 19 (7) |
| Venlafaxine | 37 ± 4 (6) | 149 ± 16 (7)1-150 |
| Tranylcypromine | 35 ± 4 (6) | 131 ± 27 (7)1-150 |
Rats were pretreated for 26 days with saline, venlafaxine (25 mg/kg/day), reboxetine (6.5 mg/kg/day), fluoxetine (4 mg/kg/day in 12% DMSO), or tranylcypromine (1.85 mg/kg/day). CRF hnRNA expression in the PVN was determined by in situ hybridization histochemistry; results are given as mean ± S.E.M. (n).
↵1-150 P < 0.05, one-way ANOVA between stress groups, Dunnett's post test.