Table 4

Differences in the 17EE metabolites generated by the P450 2B enzymes

MetaboliteP450 2B1P450 2B2P450 2B4P450 2B6
A1 +A2 13  ± 3.04-a 1.2  ± 0.42.4  ± 0.80.28  ± 0.10
B2.2  ± 0.3N.D.3.0  ± 0.90.23  ± 0.10
C2.3  ± 0.4N.D.N.D.0.18  ± 0.02
c′1.4  ± 0.43.7  ± 0.80.4  ± 0.20.38  ± 0.23
D16.4  ± 4.918  ± 4.83.9  ± 0.71.14  ± 0.23
E7.6  ± 5.0000.41  ± 0.20
F100100100100

Assay conditions were as described under Experimental Procedures. The data shown represent the average and standard deviation of four to six experiments.

• N.D., not determined.

• 4-a  Percentage of area under the peak relative to the area under the peak of 17EE.