Gender differences in hepatic microsomal activities and UGT1A6 protein content
| Female | Male | Pvalue | |||
|---|---|---|---|---|---|
| Median (25–75%) | n | Median (25–75%) | n | ||
| Acetaminophen-UGT | 117 (72–172) | 24 | 174 (109–245) | 32 | 0.047 |
| Bilirubin-UGT (UGT1A1) | 152 (111–249) | 10 | 192 (144–236) | 10 | 0.734 |
| Imipramine-UGT (UGT1A4) | 30 (22–34) | 10 | 26 (21–31) | 10 | 0.571 |
| Relative UGT1A6 protein (UGT1A6) | 8 (4–10) | 10 | 12 (7–13) | 10 | 0.076 |
| Propofol-UGT (UGT1A9) | 245 (135–322) | 10 | 291 (239–364) | 10 | 0.521 |
| Androsterone-UGT (UGT2B) | 52 (47–59) | 10 | 58 (45–66) | 10 | 0.734 |
| Phenacetin-O-deethylase (CYP1A2) | 437 (211–659) | 10 | 583 (271–802) | 10 | 0.571 |
Activities (pmol/min/mg protein) and relative UGT1A6 protein content were determined using the either entire set of liver microsomes with identified gender (n = 56; acetaminophen-UGT activities) or a subset from 10 male and 10 female donors. Data given include the median, 25 to 75 percentiles and size (n) of each group, as well as the P value for the comparison using the Mann-Whitney rank sum test.