8(R),9(S)-EET | 8/(S),9/(R)-EET | 11(R),12(S)-EET | 11(S),12(R)-EET | 14(R),15(S)-EET | 14(S),15(R)-EET | |
---|---|---|---|---|---|---|
% | ||||||
CYP2C29 | 18 | 82 | 60 | 40 | 83 | 17 |
CYP2C37 | 28 | 72 | 60 | 40 | 58 | 42 |
CYP2C38 | 94 | 6 | 93 | 7 | 56 | 44 |
CYP2C39 | 94 | 6 | 86 | 14 | 29 | 71 |
CYP2C40 | 14 | 86 | 30 | 70 | 62 | 38 |
The regiochemical and stereochemical composition of EETs formed by incubation of recombinant CYP2Cs with [1-14C]AA were quantified by HPLC and liquid scintillation as described underExperimental Procedures. Values shown are averages of at least three different experiments with standard errors less than 5%.