Calculated pharmacokinetic parameters (±S.D.).
| Dose | Body Wt. | AUC3-a | Cmax3-a | Clearance | Vss3-a | Half-Life3-b |
|---|---|---|---|---|---|---|
| mg/kg | kg | μg·h/ml | μg/ml | ml/h/kg | ml/kg | min |
| Nude mouse | ||||||
| 10 | 0.026 ± 0.002 | 26.5 | 302 | 377 | 37.4 | 3.64 |
| Rat | ||||||
| 10 | 0.266 ± 0.013 | 25.6 ± 2.61 | 240 ± 56 | 395 ± 40 | 48.3 ± 13 | 4.58 ± 0.82 |
| Cynomolgus monkey | ||||||
| 1 | 3.33 ± 0.651 | 18.8 ± 8.41 | 32 ± 6.11 | 62 ± 261 | 67 ± 411 | 24.2 ± 7.81 |
| 5 | 3.35 ± 1.171 | 67.6 ± 24.02 | 123 ± 342 | 83 ± 361 | 53 ± 9.21 | 23.0 ± 6.61 |
| 50 | 3.45 ± 0.6131 | 1050 ± 2003 | 1410 ± 1803 | 49 ± 111 | 47 ± 7.61 | 31.2 ± 5.581 |
| Chimpanzee | ||||||
| 1 | 60 ± 8.71 | 14.7 ± 1.621 | 25.4 ± 1.891 | 66.4 ± 4.031 | 37.9 ± 4.501 | 23.9 ± 4.121 |
| 5 | 53 ± 8.91 | 88.7 ± 16.42 | 138 ± 11.22 | 58.2 ± 9.291 | 36.6 ± 4.091 | 27.0 ± 5.241 |
Within a primate species, group means in the same column with different numerical superscripts are significantly different (analysis of variance; α = 0.05).
↵3-a AUC is the calculated area under the Apo2L/TRAIL serum concentration vs. time curve; Cmax is the model-predicted maximum serum concentration of Apo2L/TRAIL; Vss is the estimated volume of distribution of Apo2L/TRAIL at steady-state.
↵3-b Reported half-life was calculated from the elimination rate constant (K10).