Table 2

Pharmacokinetic studies: group assignments and dose levels

SpeciesNo. of AnimalsDose LevelDose Conc.Dose VolumeDuration of Injection
mg/kg mg/ml ml/kg
Nude mouse201052.0<5 s
SD rat41051.9<5 s
Cynomolgus monkey410.891.12<30 s
Cynomolgus monkey4510.10.50<30 s
Cynomolgus monkey45019.12.62<30 s
Chimpanzee3150.2050 to 80 s
Chimpanzee4551.050 to 80 s
  • SD, Sprague-Dawley.