Dose | Day 0 | Day 3 | Day 7 | Day 10 | Day 14 | Day 17 | Day 21 | Day 24 |
---|---|---|---|---|---|---|---|---|
mg/kg/day | ||||||||
0 | 270 ± 27 | 530 ± 82 | 1000 ± 160 | 1700 ± 190 | N.A. | N.A. | N.A. | N.A. |
30 | 260 ± 27 | 130 ± 20 | 90 ± 21 | 130 ± 23 | 280 ± 60 | 520 ± 98 | 940 ± 180 | N.A. |
60 | 270 ± 25 | 120 ± 9.1 | 70 ± 10 | 65 ± 11 | 160 ± 31 | 260 ± 56 | 580 ± 130 | N.A. |
90 | 270 ± 25 | 97 ± 9.0 | 48 ± 9.2 | 61 ± 9.0 | 110 ± 17 | 160 ± 26 | 340 ± 82 | 550 ± 120 |
120 | 270 ± 25 | 77 ± 14 | 130 ± 93 | 51 ± 14 | 140 ± 33 | 180 ± 71 | 400 ± 150 | 600 ± 260 |
Data are group average tumor volumes ± S.E. ( n = 10 mice/group).
N.A., not available. Mice were euthanized due to large tumor size.