Table 1

Drug effects on HERG deactivation kinetics at −60 mV

Conditionτfastτslown
ms s
Control314.8  ± 50.21.4  ± 0.310
3 μM Cocaine587.3  ± 88.81-150 2.6  ± 0.41-160
Control470.4  ± 32.02.2  ± 0.111
1 μM Cocaethylene766.5  ± 36.61-159 4.0  ± 0.31-160
Control628.2  ± 86.12.9  ± 0.47
200 μM Methylecgonidine702.8  ± 139.14.2  ± 1.2

Tail currents recorded at −60 mV following a 5-s pulse to +60 mV in the presence or absence of drug.

  • 1-150P < 0.01,

  • 1-160P < 0.001;

  • 1-159P < 0.0001 (by Student's paired t test).