Time | Visual Analogs | Subject-Rated Adjectives | Observer-Rated Adjectives | ARCI | Manual Respiratory Rate | Pupil Photographs | |
---|---|---|---|---|---|---|---|
min | |||||||
Pretreatment period (all sessions)1-a | −45 | X | X | X | X | X | X |
Enadoline, butorphanol, or placebo (i.m.) | −30 | ||||||
−25 | X | X | X | ||||
−15 | X | X | X | X | X | X | |
−5 | X | X | X | ||||
Cocaine dose-effect sessions only (Monday) | |||||||
Cocaine (0, 20, and 40 mg i.v.) | 0 | ||||||
0–14 | X | ||||||
5 | X | X | |||||
10 | X | ||||||
15 | X | X | X | X | X | ||
30 | X | X | X | X | X | ||
45 | X | X | X | X | X | ||
Cessation cocaine self-administration sessions only (Wednesday) | |||||||
Cocaine sample (40 mg i.v.) | 0 | ||||||
0–4 | X | ||||||
5 | X | ||||||
10 | X | ||||||
15 | X | X | X | X | X | X | |
Cessation and relapse self-administration sessions (Wednesday and Friday) | |||||||
Six choice trials: cocaine versus money | 01-b | 1-c | |||||
0–4 | X | ||||||
5 | 1-c | X | X | X | |||
10 | X | X | X | X | X |