Table 4

Summary of NSAID-induced effects on cell cycle and protein expression

TreatmentCell Cycle AccumulationCyclin D1Cyclin ECyclin B1Cyclin Ap21p27
PaCa-2
 SulindacG2/M
 IndomethacinG0/G1
 NS-398G0/G1
 GemcitabineS
BxPC-3
 SulindacG0/G1, G2/M
 IndomethacinG0/G1
 NS-398G0/G1
 GemcitabineS
  • ↓, ↑, or — indicates a decrease, increase, or no change, respectively, in protein expression relative to control cells.