Table 7

A, quantitative EEG spectral analysis in the rat sensorimotor cortex: effects of SL651498 and diazepam. Statistically significant increases (% variations) of absolute percent of total power values for each frequency band and total power after increasing doses of SL651498 (3, 10, and 30 mg/kg) or diazepam (0.3, 1 and 3 mg/kg) in rats; B, effects of SL651498 on sleep-wakefulness cycle in rats recorded during the dark period: global analysis of a 6-h period. n = 6.



Compound	Dose	Delta Band	Theta Band	Alpha 1 Band	Alpha 2 Band	Beta 1 Band	Beta 2 Band	Total Power
	mg/kg
SL651498 (p.o.)	10	N.S.	N.S.	N.S.	N.S.	N.S.	⁺37 to ⁺46
	30	⁺66 to ⁺90	N.S.	⁺82 to ⁺128	⁺143 to⁺189	⁺105 to ⁺158	⁺46 to ⁺91	⁺30 to ⁺56%

SL651498 (i.p.)	10	⁺37 to ⁺56	N.S.	N.S.	N.S.	N.S.	N.S.
	30	⁺67 to ⁺90	N.S.	⁺51 to ⁺97	⁺70 to⁺107	⁺52 to ⁺94	⁺30 to ⁺39	⁺58 to ⁺79%
Diazepam (i.p.)	1	⁺82 to ⁺149	N.S.	⁺127 to ⁺145	⁺155 to⁺216	⁺198 to ⁺270	⁺167 to ⁺261	⁺93 to ⁺126%
	3	⁺115 to ⁺210	⁺50 to ⁺72	⁺116 to ⁺241	⁺178 to ⁺334	⁺255 to ⁺450	⁺167 to ⁺261	⁺115 to 202%



SL651498	W%	SWS%	PS%	nPS%	xPS%	PS lat
						min
10 mg/kg, p.o.	0	⁺3	−27	−29	−5	46
24 h after	⁺6	−11	−26	−29	⁺5	100

N.S., not significant; W, wakefulness; SWS, slow wave sleep; PS, paradoxical sleep; nPS, number of PS phases; xPS, mean duration of PS phases; PS lat, delay of the onset of the first PS phase.
7-150 P < 0.05 (Student's t test for paired values).