Table 6

Effects of acute and repeated (twice per day for 13 days) treatments with diazepam and SL651498 on several behavioral responses displayed by Swiss mice before (locomotor activity), during (risk assessment and defensive attack), and after (contextual defense) exposure to a Long Evans rat in the mouse defense test battery

	Dose	Locomotor Activity		Risk Assessment		Defensive Attack
	Dose	Line Crossings	Stops	Orientations	Approaches-Withdrawals	Bitings	Escape Attempts
	mg/kg
Acute Experiments
SL651498 (i.p.)	0	107.3 ± 12.5	11.6 ± 1.6	8.9 ± 1.8	1.1 ± 0.2	2.5 ± 0.3	35.1 ± 2
	1	137 ± 6	11.1 ± 1.4	8.2 ± 1.4	1.3 ± 0.4	2.7 ± 0.1	30.5 ± 2.3
	3	143.5 ± 12.5	11.8 ± 2	9.8 ± 1.8	1.5 ± 0.3	2.3 ± 0.3	26.9 ± 2.8
	10	121.6 ± 8.2	5.2 ± 1.2^6-150	4 ± 1.2^6-150	1.5 ± 0.4	0.8 ± 0.3^6-150	11.8 ± 2.2^6-150
Diazepam (i.p.)	0	127.6 ± 9.6	13.3 ± 2	9.6 ± 1.9	0 ± 0	2.3 ± 0.3	30.6 ± 3.8
	0.5	138.6 ± 16.1	10.1 ± 1.4	5.9 ± 1.5	0.3 ± 0.2	1.8 ± 0.2	27.3 ± 4.9
	1	139.5 ± 22	3.6 ± 0.6^6-150	2.3 ± 0.6^6-150	0.8 ± 0.3	0.8 ± 0.2^6-150	24.5 ± 5.4
	3	95.1 ± 13.7	3.1 ± 0.8^6-150	1.3 ± 0.4^6-150	1.6 ± 0.6^6-150	0.1 ± 0.1^6-150	19 ± 5.8

SL651498 (p.o.)	0	123.6 ± 10	9.8 ± 0.2	6.7 ± 1.1	0 ± 0	2.6 ± 0.2	35.2 ± 11.7
	3	120.9 ± 9	8.9 ± 0.2	5.4 ± 0.4^6-150	0 ± 0	2 ± 0.2^6-150	32.6 ± 10.9
	10	111.7 ± 8	6.2 ± 0.4^6-150	3 ± 0.3^6-150	0.1 ± 0.1	0.1 ± 0.1^6-150	17.4 ± 5.8^6-150
	30	99.7 ± 10.9	5 ± 0.6^6-150	1.8 ± 0.4^6-150	0.6 ± 0.3^6-150	0.1 ± 0.1^6-150	16.1 ± 5.4^6-150
Diazepam (p.o.)	0	153.3 ± 8.2	9.3 ± 0.2	6.9 ± 0.5	0.1 ± 0.1	2.6 ± 0.2	37.2 ± 3.7
	1	153.3 ± 9.2	8.8 ± 0.3	5.5 ± 0.5^6-150	0.2 ± 0.1	2.2 ± 0.3	29.7 ± 2.9
	3	136.6 ± 7.2	6.6 ± 0.3^6-150	3.3 ± 0.5^6-150	0.7 ± 0.3	0.3 ± 0.2^6-150	18.8 ± 3.5^6-150
	10	111.3 ± 4.8^6-150	5.2 ± 0.3^6-150	1.4 ± 0.3^6-150	2.3 ± 0.4^6-150	0 ± 0^6-150	3.2 ± 1.2^6-150
	20	111.1 ± 8^6-150	4.8 ± 0.4^6-150	1.3 ± 0.3^6-150	2.6 ± 0.5^6-150	0 ± 0^6-150	4.2 ± 2.2^6-150
Repeated Experiments
SL651498 (acute, p.o.)	0	116.6 ± 10.3	6.8 ± 1.2	9.3 ± 0.8	0.1 ± 0.1	2.5 ± 0.2	30.1 ± 5.4
	1	103.6 ± 10.2	5.6 ± 1	8.3 ± 1	0.9 ± 0.4	1.4 ± 0.3	26.8 ± 3.2
	3	122.4 ± 12.9	4.8 ± 1.1	6.8 ± 1	0.8 ± 0.3	1.3 ± 0.4^6-150	23 ± 3.2
	10	110.0 ± 8.7	2.1 ± 0.5^6-150	4.4 ± 0.6^6-150	0.5 ± 0.3	0.3 ± 0.2^6-150	21.3 ± 3.9
Diazepam (acute, p.o.)	3	94.1 ± 7.2	1.6 ± 0.6^6-150	3.4 ± 0.7^6-150	1.5 ± 0.5	0 ± 0^6-150	16 ± 4.6
SL651498 (repeated, p.o.)	1	90.9 ± 10.8	4.4 ± 0.9	6.9 ± 0.7	0.4 ± 0.2	1.8 ± 0.4	24.9 ± 2.7
	3	119.4 ± 9.1	3.8 ± 0.7^6-150	5.4 ± 0.9^6-150	1 ± 0.4	0.8 ± 0.5^6-150	22.9 ± 5
	10	103.9 ± 5.3	4.4 ± 0.8	6.5 ± 1^6-150	1.3 ± 0.4	0 ± 0^6-150	24.1 ± 3.4
Diazepam (repeated, p.o.)	3	104 ± 11.5	3.4 ± 0.6^6-150	5.1 ± 0.7^6-150	1.4 ± 0.4	0 ± 0^6-150	20.9 ± 3.5

Data represent mean ± SEM. n = 8 to 12.

↵6-150 P < 0.05 (relative to zero drug treatment, Dunnett's t test).