Tests | MED (*ED50) i.p. (p.o.) | |||
---|---|---|---|---|
SL651498 | Diazepam | Clorazepate | Lorazepam | |
mg/kg | ||||
Isoniazid-induced convulsions in mice | 7* | 0.7* | 2* | 2* |
PTZ-induced convulsions in mice | 9.5* | 0.3* | 0.4* | |
Electroshock-induced convulsions in mice | ≈40* | 1.5* | 2.5* | |
Lever-pressing conflict test in rats | 3 | 2.5 | 3 | |
Drinking conflict test in rats | 10 (10) | 1 (10) | 10 (10) | 0.1 |
Elevated plus-maze in rats | 1 (3) | 3 (20) | 10 (10) | 0.1 (1) |
Light/dark test in mice | 10 | 2 | 2 | 1 |
Four-plate test in mice | 4 | (2) | ||
Mouse defense test battery | 3 (3) | 0.5 (1) | 10 | |
Rotarod in mice | 100 | 10 | 3 | 1 |
Rotarod in rats | 30 | 10 | 1 | 0.3 |
Grip Strength in mice | 56* | 3.5* | 0.6* | |
Grip Strength in rats | 27* | 2.9* | 0.3* | |
EEG in rats | 30 (30) | 1 | 0.1 | |
Horizontal wire test in mice | (>30) | (1) | ||
Interaction with alcohol in mice | (30) | (1) |
Comparison with diazepam and other BZs (unpublished data).
MED, minimal effective dose; PTZ, pentylenetetrazole.