Cardiovascular effects of α-CGRP (0.3 μg/kg, i.v.) and α-CGRP[8-37] (30 μg/kg/min, i.v.) in anesthetized rats
| Baseline | Peak Response | % Change | ||
|---|---|---|---|---|
| Mean arterial pressure (mm Hg) | ||||
| α-CGRP | (n = 14) | 103 ± 4 | 86 ± 5 | −17 ± 31-150 |
| α-CGRP[8-37] | (n = 9) | 98 ± 3 | 97 ± 3 | −1 ± 1 |
| Carotid blood flow (ml/min) | ||||
| α-CGRP | (n = 14) | 8.3 ± 0.5 | 11.3 ± 0.7 | +36 ± 31-150 |
| α-CGRP[8-37] | (n = 9) | 8.4 ± 0.8 | 8.2 ± 0.7 | −1 ± 3 |
| Heart rate (beat/min) | ||||
| α-CGRP | (n = 14) | 300 ± 10 | 305 ± 10 | +2 ± 11-150 |
| α-CGRP[8-37] | (n = 9) | 318 ± 12 | 312 ± 13 | −2 ± 1 |
↵1-150 p < 0.01, significant difference from baseline.