Table 1

Effects of adventitially administered RWJ-58259 on vascular injury in response to balloon angioplasty in the carotid artery of rats

Group	No.	Area, mm²		Thickness, μM		Vessel Dimensions, mm²
Group	No.	Intima	Media	% Stenosis	Intima	Media	I/M	Lumen	Vessel
Vehicle	10	0.129 ± 0.005	0.123 ± 0.006	44 ± 3	77 ± 5	58 ± 2	1.35 ± 0.09	0.231 ± 0.026	0.480 ± 0.028
1 mg	9	0.118 ± 0.010	0.118 ± 0.007	38 ± 2	68 ± 5	55 ± 2	1.24 ± 0.09	0.258 ± 0.019	0.482 ± 0.026
5 mg	9	0.110 ± 0.008	0.113 ± 0.007	36 ± 3	63 ± 4	53 ± 2	1.19 ± 0.09	0.239 ± 0.025	0.447 ± 0.035
10 mg	8	0.084 ± 0.007^1-150	0.121 ± 0.006	26 ± 3^1-150	45 ± 5^1-150	54 ± 2	0.83 ± 0.10^1-150	0.320 ± 0.031	0.507 ± 0.034

I/M, intima/media.
↵1-150 P < 0.05, significantly different from vehicle by one-way analysis of variance.