Agonist | EC50, nM (pEC50 ± S.E.M.) | |||
---|---|---|---|---|
cAMP Accumulation (PC12 Cells) | Coronary Conductance (Rat Isolated Heart) | |||
CGS21680 | 18 (7.75 ± 0.03) | n = 3 | 0.54 (9.27 ± 0.03) | n = 3 |
CVT-2995 | 6.6 (8.82 ± 0.25) | n = 3 | 0.68 (9.17 ± 0.03) | n = 5 |
CVT-3146 | 291 (6.54 ± 0.03) | n = 3 | 6.40 (8.19 ± 0.04) | n = 4 |
CVT-3032 | 613 (6.21 ± 0.02) | n = 3 | 66.50 (7.18 ± 0.07) | n = 4 |
CVT-3033 | 487 (6.31 ± 0.01) | n = 3 | 67.95 (7.19 ± 0.08) | n = 4 |
WRC0470 | N.D. | 0.62 (9.19 ± 0.06) | n = 5 | |
Adenosine | N.D. | 59.20 (7.24 ± 0.11) | n = 4 |
Values are the mean concentrations of agonists that caused 50% increases in cAMP accumulation or coronary conductance (EC50and pEC50).
N.D., not determined.