Effects of organic anions (300 μM) on initial uptake rate of [14C]pravastatin (10 μM) by human hepatocytes and on uptake of [14C]pravastatin (30 μM) by LST-1 cRNA-injected oocytes
| Pravastatin Uptake | ||
|---|---|---|
| Human Hepatocytes | LST-1-Expressing Oocytes | |
| % of control | ||
| Control | 100.0 | 100.0 |
| +TCA | 24.5 ± 8.8 | 19.7 ± 3.9 |
| +SVA | 6.5 ± 5.8 | 16.0 ± 1.3 |
| +BSP | 4.7 ± 2.6 | 13.6 ± 2.0 |
| +PAH | 121.0 ± 8.6 | 118.0 ± 4.9 |
Data are expressed as the mean ± S.E. of three uptake measurements.
TCA, taurocholic acid; SVA, simvastatin acid; BSP, bromosulfophthalein; PAH, para-aminohippurate.