Table 2

Enzyme kinetic analyses of the formation of R-norfluoxetine by human liver microsomes

Microsomal SampleKm1Vmax1KiKm2Vmax2
μM pmol/min/mg μM μM pmol/min/mg
HLO1.6  ± 0.42-a 11  ± 3n  / a34  ± 874  ± 4
HLG8.0  ± 1.047  ± 4294  ± 112n  / an  / a
HLM5.9  ± 0.953  ± 4116  ± 19n  / an  / a
HLK2-b 20  ± 451  ± 965  ± 17n  / an  / a

  • n/a, not applicable.

  • ↵2-a  Parameter estimate ± standard error of the parameter estimate.

  • ↵2-b  Human liver deficient in CYP2D6.