Probenecid | CLtotal | Cpss | fp | Chss | fh |
---|---|---|---|---|---|
μmol/min/kg | ml/min/kg | μM | μM | ||
1.1 | 4.11 ± 0.07 | 243 ± 4 | 0.243 ± 0.005 | 205 ± 12 | 0.204 ± 0.011 |
2.2 | 3.48 ± 0.04 | 633 ± 19 | 0.214 ± 0.008 | 420 ± 40 | 0.185 ± 0.040 |
3.3 | 4.69 ± 0.08 | 704 ± 12 | 0.258 ± 0.005 | 541 ± 23 | 0.230 ± 0.009 |
4.4 | 4.86 ± 0.15 | 905 ± 12 | 0.286 ± 0.005 | 831 ± 169 | 0.159 ± 0.035 |
Both methotrexate (0.164 μmol/min/kg) and probenecid were infused intravenously at the indicated infusion rates. The steady-state probenecid concentrations in plasma and liver were determined, and pharmacokinetic parameters (mean ± S.E. of four rats) were calculated.