Mean ± S.E.M. pharmacokinetic parameters of celecoxib after single i.v. administration at 5 mg/kg to dogs
| Dose | No. of Dogs | Phenotype | Vdss | t1/2 | Cl | AUC0–∞ |
|---|---|---|---|---|---|---|
| mg/kg | l/kg | h | ml/min/kg | (μg/ml)h | ||
| 5 | 6 | EM | 1.9 ± 0.08 | 1.3 ± 0.2 | 21.8 ± 2.3 | 4.04 ± 0.44 |
| 5 | 6 | PM | 2.3 ± 0.06 | 5.1 ± 0.5 | 7.4 ± 0.5 | 11.5 ± 0.75 |
Vdss, apparent volume of distribution at steady state; Cl, clearance.