Table 1

Direction of significant differences between knockout (KO) and wild-type (WT) mice in transgenic studies on commonly tested nociceptive phenotypes in which 129 mice differ significantly from C57BL/6 mice

KO > WTWT > KO
C57BL/6 > 129101-a 411-b
129 > C57BL/631-b 21-a

Data are culled from 33 transgenic studies of pain in which one or more of the following common assays were performed: abdominal constriction (writhing) test, autotomy, formalin test, Hargreaves' test of paw withdrawal, hot-plate test, tail-clip test, tail-withdrawal/flick test, von Frey test. On all but one of these assays, C57BL/6 mice are significantly more sensitive than 129 mice (C57BL/6 > 129; see Fig. 1A). On the von Frey test, 129 mice are significantly more sensitive than C57BL/6 mice (129 > C57BL/6; see Fig. 1A).

  • ↵1-a  Cases in which KO mice exhibited C57BL/6-like phenotypes (12 of 56).

  • ↵1-b  Cases in which KO mice exhibited 129-like phenotypes (44 of 56).