Table 1

Inhibitory effects of i.v. and p.o. roflumilast on allergen-induced early airway reaction in the guinea pig

Compound, Administration Route, DoseInhibition of OVA-Induced Decrease of ConductanceED50 i.v./p.o.
% μmol/kg
Roflumilast i.v. (μmol/kg)
 0.00110 (−9, 30) N.S.
 0.0127 (8, 47)1-150 0.11 (0.03, 0.38)
 0.151 (31, 74)1-150
 168 (48, 92)1-165
Roflumilast p.o. (μmol/kg)
 0.01−13 (−29, 2) N.S.
 0.124 (6, 42) N.S.1.53 (0.54, 4.36)
 144 (26, 63)1-160
 356 (38, 76)1-165

In vivo effects of i.v. and p.o. administered roflumilast (1 h prior to antigen challenge) on OVA-induced not histamine-mediated decrease of airway conductance in anesthetized and mechanically ventilated guinea pigs. Results represent percentage of inhibition (negative values display amplification of the effect). ED50 values are given as means and 95% confidence limits (in parentheses) and describe the half-maximal inhibition of the OVA-induced decrease of airway conductance based on AUC (1 to 12 min after challenge).n = 6 per roflumilast dose and placebo.

  • 1-150p < 0.05,

  • 1-160p < 0.01,

  • 1-165p < 0.001; N.S., not significant.