Table 1

Comparison of cellular accumulation ratio of KB-3-1/KB-V1 and transcellular transport ratio of L-MDR1 and LLC-PK1

Cellular Accumulation Ratio (KB-3-1)/(KB-V1)Transcellular Transport Ratio (B-to-A)/(A-to-B)
Digoxin4.2  ± 0.910.0  ± 1.3
Vinblastine46.3  ± 12.012.7  ± 1.5
Progesterone1.1  ± 0.10.9  ± 0.1
Indinavir11.4  ± 1.59.9  ± 0.8
Ritonavir5.3  ± 1.415.8  ± 1.8
Compound X1.6  ± 0.11.8  ± 0.1
Compound Y1.2  ± 0.21.2  ± 0.2
Diazepam1.2  ± 0.11.0  ± 0.1
MK-08260.9  ± 0.11.1  ± 0.1
MK-09910.8  ± 0.21.1  ± 0.1
Compound A10.7  ± 0.417.6  ± 1.9
Compound B6.2  ± 1.44.3  ± 0.2
Compound C12.4  ± 2.910.3  ± 0.3
Compound D5.4  ± 0.613.7  ± 2.8

The cellular accumulation ratio of KB-3-1/KB-V1 was calculated at 2-h incubation. The transcellular transport ratio of L-MDR1 is represented as B-to-A versus A-to-B transported amounts after a 3-h incubation. Results shown are mean ± S.E. (n = 3–8).