IC50 values for the inhibition of COX-1 and COX-2 in the human whole blood assays
| IC50 COX-1 | n (Donor) | IC50 COX-2 | n (Donor) | COX-2 Selectivity Ratio of IC50 COX-1/COX-2 | |
|---|---|---|---|---|---|
| μM | μM | ||||
| Etoricoxib | 116 ± 18 | 12 | 1.1 ± 0.1 | 26 | 106 |
| Rofecoxib | 18.8 ± 0.9 | 211 | 0.53 ± 0.02 | 614 | 35 |
| Valdecoxib | 26.1 ± 4.3 | 11 | 0.87 ± 0.11 | 14 | 30 |
| Celecoxib | 6.7 ± 0.9 | 13 | 0.87 ± 0.18 | 18 | 7.6 |
| Nimesulide | 4.1 ± 1.2 | 6 | 0.56 ± 0.12 | 6 | 7.3 |
| Diclofenac | 0.15 ± 0.04 | 10 | 0.05 ± 0.01 | 16 | 3.0 |
| Etodolac | 9.0 ± 2.5 | 3 | 3.7 ± 0.7 | 6 | 2.4 |
| Meloxicam | 1.4 ± 0.4 | 6 | 0.70 ± 0.28 | 5 | 2.0 |
| Indomethacin | 0.19 ± 0.02 | 36 | 0.44 ± 0.07 | 34 | 0.4 |
| Ibuprofen | 4.8 ± 3.5 | 5 | 24.3 ± 9.5 | 7 | 0.2 |
| 6-MNA | 28.9 ± 5.5 | 3 | 154 ± 51 | 5 | 0.2 |
| Piroxicam | 0.76 ± 0.05 | 6 | 9.0 ± 1.3 | 16 | 0.08 |
| JTE-522 | >30 | 5 | >30 | 6 |
Values are means ± S.E.; inhibitors are ranked by order of selectivity for COX-2.
6-MNA, 6-methoxy-2-naphthaleneacetic acid.