Table 3

Dialkylated benzimidazolones

Compound No.	Compound Name	⁸⁶Rb⁺ Uptake Relative Activity		Log P
Compound No.	Compound Name	at 60 μM	at 1 mM	Log P
9	1,3-Dimethyl-1,3-dihydro-2H-benzimidazol-2-one	0.42	0.72	1.94
10	1,3-Diethyl-1,3-dihydro-2H-benzimidazol-2-one	0.58	0.18	2.83
11	1,3-Dipropyl-1,3-dihydro-2H-benzimidazol-2-one	0.48	0.30	3.46
12	1,3-Diisopropyl-1,3-dihydro-2H-benzimidazol-2-one	0.19	0.15	2.83
13	1-Ethyl-3-methyl-1,3-dihydro-2H-benzimidazol-2-one	0.0	0.92	2.29
14	1-Ethyl-3-propyl-1,3-dihydro-2H-benzimidazol-2-one	0.0	0.76	3.10
15	1-Ethyl-3-isopropyl-1,3-dihydro-2H-benzimidazol-2-one	0.80	0.16	3.04
16	1-Ethyl-3-butyl-1,3-dihydro-2H-benzimidazol-2-one	0.61	0.0	3.49