Table 1

Binding affinities and selectivities of various cannabinoid ligands to membranes of CHO cells expressing human CB₁ and CB₂, mouse cerebellum as CB₁ preparation and CHO cells expressing mouse CB₂, and membrane of rat cerebellum as CB₁preparation and rat splenocyte as CB₂ preparation

Test Compounds	K_i (nM)
Test Compounds	Human CB₁	Human CB₂	Selectivity for CB₂	Mouse CB₁	Mouse CB₂	Selectivity for CB₂	Rat CB₁	Rat CB₂	Selectivity for CB₂
JTE-907	2370 ± 297	35.9 ± 7.32	66	1060 ± 90.0	1.55 ± 0.09	684	1050 ± 35.4	0.38 ± 0.1	2760
SR144528	50.3 ± 8.37	1.99 ± 0.94	25	20.1 ± 4.20	0.04 ± 0.00	503	27.6 ± 2.89	0.24 ± 0.02	115
Win55212-2	9.87 ± 1.52	0.29 ± 0.12	34	0.41 ± 0.16	0.56 ± 0.02	0.7	0.14 ± 0.07	1.30 ± 0.33	0.1
Δ⁹-THC	5.05 ± 0.65	3.13 ± 0.34	1.6	8.33 ± 3.45	1.73 ± 0.09	4.8	13.5 ± 3.81	6.80 ± 2.28	2

Each value represents mean ± S.E.M. of three experiments.