Effect of coincubation of NOS inhibitors with l-arginine and d-arginine on NE sensitivity in mesenteric arteries from control and diabetic rats
| Mesenteric Arteries | Inhibitor | pD2 (Untreated) | pD2(Inhibitor) | pD2 (Inhibitor +l-Arginine) | pD2 (Inhibitor +d-Arginine) |
|---|---|---|---|---|---|
| Control (endothelium-intact) | l-NIO | 6.29 ± 0.08 | 7.11 ± 0.074-150 | 6.28 ± 0.11 | 7.13 ± 0.094-150 |
| Diabetic (endothelium-denuded) | EIT | 7.22 ± 0.08 | 8.07 ± 0.124-150 | 7.46 ± 0.32 | 8.13 ± 0.164-150 |
Results are expressed as the mean ± S.E.M. of values obtained in arteries from five control and five diabetic rats.
↵4-150 p < 0.05 compared with untreated values.