Infusion | Probe Agent | Inhibitor | Mean M/S (S.D.) | Mean Cls, l/h/kg (S.D.) | ||
---|---|---|---|---|---|---|
Control | +Inhibitor | Control | +Inhibitor | |||
1 | Cimetidine 0.5 mg/h | Nitrofurantoin 3.75 mg/h | 26.6 (4.9) | 17.7 (5.6) | 2.00 (0.27) | 1.65 (0.23) |
2 | Nitrofurantoin 0.5 mg/h | Cimetidine 30 mg/h | 21.6 (8.8) | 19.7 (6.1) | 2.56 (0.39) | 1.42 (0.41) |
3 | Cimetidine 0.5 mg/h | Probenecid 15 mg/h | 15.5 (3.6) | 21.5 (7.7) | 1.96 (0.50) | 2.13 (0.48) |
4 | Nitrofurantoin 0.5 mg/h | Probenecid 15 mg/h | 25.7 (9.8) | 32.2 (8.5) | 3.07 (0.69) | 2.66 (0.44) |
5 | p-Aminohippurate sodium 9 mg/h | Probenecid 15 mg/h | 0.099 (0.040) | 0.169 (0.138) | 1.27 (0.60) | 0.70 (0.28) |
6 | Probenecid 8.33 mg/h | None | 0.212 (0.058) | 0.209 (0.037) |
Treatment groups and infusion regimens administered to lactating female rats. Boldface indicates p < 0.05 vs. control.