Peptide | hCRF1 EC50 | hCRF2αEC50 | xCRF1 EC50 | xCRF2EC50 |
---|---|---|---|---|
nM | ||||
hCRF | 0.64 ± 0.04 | 8.11 ± 0.366-a | 0.72 ± 0.06 | 9.81 ± 0.496-a |
oCRF | 0.61 ± 0.05 | 29.1 ± 1.76-b | 8.14 ± 0.276-c | 32.1 ± 2.16-b |
rUCN | 1.69 ± 0.096-d | 1.86 ± 0.116-e | 2.29 ± 0.146-e | 1.74 ± 0.136-e |
hUCN | 1.81 ± 0.116-d | 1.52 ± 0.096-e | 2.34 ± 0.156-e | 1.94 ± 0.136-e |
Urotensin I | 0.52 ± 0.04 | 0.60 ± 0.05 | 0.78 ± 0.06 | 0.46 ± 0.04 |
Sauvagine | 0.42 ± 0.03 | 0.34 ± 0.03 | 36.9 ± 1.16-f | 0.24 ± 0.02 |
The data are the mean ± S.E. of four stimulations.
Statistically significant differences:
↵6-a p < 0.0001 vs. rUCN, hUCN, urotensin I, and sauvagine;
↵6-b p < 0.0001 vs. hCRF, rUCN, hUCN, urotensin I and sauvagine;
↵6-c p < 0.0001 vs. hCRF, rUCN, hUCN, and urotensin I;
↵6-d p < 0.0001 vs. hCRF, oCRF, urotensin I, and sauvagine;
↵6-e p < 0.01 vs. urotensin I and sauvagine;
↵6-f p < 0.0001 vs. hCRF, oCRF, rUCN, hUCN, and urotensin I.