Inhibition of AK and intact cell ADO phosphorylation
| AK IC50 | Cell IC50 | |
|---|---|---|
| nM | ||
| ABT-702 | 1.7 ± 0.5 | 50.7 ± 8.0 |
| 5′d-5IT | 0.9 ± 0.1 | 68.1 ± 7.5 |
| 5IT | 9.3 ± 1.5 | 16.3 ± 0.3 |
| NH2dADO | 9.2 ± 2.1 | 6330 ± 880 |
All values are the mean ± S.E.M. of at least three separate observations.