Effect of SCH-23390, eticlopride, or PBN pretreatment on the decrease in [3H]DA uptake in rat striatal synaptosomes induced by a single administration of METH
| Pretreatment/Treatment | [3H]DA Uptake ± S.E.M. |
|---|---|
| fmol/μg protein | |
| Saline/saline | 1.27 ± 0.08 |
| SCH-23390/saline | 1.32 ± 0.10 |
| Saline/METH | 0.93 ± 0.041-150 |
| SCH-23390/METH | 0.90 ± 0.041-150 |
| Saline/saline | 1.62 ± 0.05 |
| Eticlopride/saline | 1.42 ± 0.07 |
| Saline/METH | 1.07 ± 0.041-150 |
| Eticlopride/METH | 1.14 ± 0.041-150 |
| Saline/saline | 1.23 ± 0.06 |
| PBN/saline | 1.27 ± 0.04 |
| Saline/METH | 0.99 ± 0.071-150 |
| PBN/METH | 0.91 ± 0.051-150 |
Rats received SCH-23390 (0.5 mg/kg i.p.), eticlopride (0.5 mg/kg i.p.), PBN (150 mg/kg i.p.), or vehicle (1 ml/kg) 15 min before METH (15 mg/kg s.c.) or saline (1 ml/kg s.c.) treatment and were decapitated 1 h later.
↵1-150 Values different from respective saline-treatment controls (P < .05).