Table 3

Pharmacokinetic parameters describing the hepatobiliary disposition of APAP, AG, and AS

	Control	TR⁻
K _OTHER(min⁻¹)	0.003 ± 0.001	N/A
K _AG(min⁻¹)	0.007 ± 0.001	0.010 ± 0.003
V _maxAS (μg/ml/min/g of liver)	0.106 ± 0.037	0.143 ± 0.036
K _PAG(min⁻¹)	0.028 ± 0.004	0.206 ± 0.095^3-150
K _BAG (min⁻¹)	0.027 ± 0.016	N/A
K _PAS(min⁻¹)	0.115 ± 0.051	0.108 ± 0.058
K _BAS (min⁻¹)	0.007 ± 0.003	0.0005 ± 0.0002^3-150
CL_AS (ml/min/g of liver)	0.045 ± 0.013	0.132 ± 0.073
V(ml)	92.8 ± 5.7	95.3 ± 8.7

Estimated formation rate constant (K), basolateral (K_P) and biliary (K_B) elimination rate constants, clearance of AS (CL_AS) from perfusate to hepatocytes, and the apparent volume of distribution (V) of APAP generated from fitting the model depicted in Fig. 2 to isolated perfused liver data from control and TR⁻rats.^3-a,^3-b

N/A, not applicable.
↵3-a Mean ± S.D.,n = 4 for control group, n = 5 for TR⁻ group.
↵3-b K_mAS was assumed to be 17 μg/ml (see Results).
↵3-150 P < .05, control vs. TR⁻.