Table 1

d -[3H]threo-MP or metabolite(s) concentrations (nmol/g) in brain and plasma after administration of 5 mg/kg MP via gavage or intraperitoneal injection

RouteCerebellumStriatumPlasma
Oral5.2  ± 1.86.4  ± 3.24.2  ± 0.91
Intraperitoneal13  ± 6.71-a 16  ± 9.11-a 11.2  ± 6.21-b

Values are mean ± S.D. Superscript letters correspond to post hoct tests showing significant difference of intraperitoneal injection from gavage (oral).

  • 1-a  P < .05.

  • 1-b  P < .001.