Table 1

Mibefradil block of voltage-gated calcium current

ReferenceCell TypeChannelCharge CarrierTemperatureKD
°C μM
Mehrke et al., 1994 hMTCNative T30 mM Ba2+ 19–222.7
Mishra and Hermsmeyer, 1994b Rat vascular smooth muscleNative T20 mM Ba2+ 230.2
Randall and Tsien, 1997 Undifferentiated NG108-15Native T10 mM Ba2+ Room temp.1.1
Cribbs et al., 1998 HEK293α1H10 mM Ba2+ Room temp.1.4
Todorovic and Lingle, 1998 Rat DRGNative T10 mM Ba2+ 20–233.0
Lui et al., 1999 Human myoblastsNative T10 mM Ba2+ N.R.0.7
Viana et al., 1997 Rat spinal motoneuronsNative T5 mM Ba2+ 20–241.4
McDonough and Bean, 1998 Rat cerebellar Purkinje neuronsNative T5 mM Ba2+ 351.0
Mehrke et al., 1994 hMTCNative T30 mM Ca2+ 19–220.2
Arnoult et al., 1998 Mouse spermatogenic cellsNative T10 mM Ca2+ 254.7
Ertel and Clozel, 1997; Benardeau and Ertel, 1998 Guinea pig atrial myocytesNative T5 mM Ca2+ N.R.1.6
Clozel et al., 1997 Vascular smooth muscleNative T5 mM Ca2+ N.R.0.1
Mehrke et al., 1994 CHOα1Cb30 mM Ba2+ 19–2218.6
Welling et al., 1995 CHOα1Cb30 mM Ba2+ Room temp.6.3
Lacinova et al., 1995 CHOα1Ca30 mM Ba2+ N.R.4.9
Schuster et al., 1996 HEK293α1Cb30 mM Ba2+ N.R.2.5
Seisenberger et al., 1995 HEK293α1C30 mM Ba2+ Room temp.1.7
Mishra and Hermsmeyer, 1994b Rat vascular smooth muscleNative L20 mM Ba2+ 232.6
Lui et al., 1999 Human myoblastsNative L10 mM Ba2+ N.R.2.0
Bezprozvanny and Tsien, 1995 Xenopusoocyteα1C5 mM Ba2+ 21–2321.0
Viana et al., 1997 Rat spinal motoneuronsNative L5 mM Ba2+ 20–241.4
Ertel and Clozel, 1997; Benardeau and Ertel, 1998 Guinea pig atrial myocytesNative L5 mM Ca2+ N.R.28.0
Clozel et al., 1997 Vascular smooth muscleNative L5 mM Ca2+ N.R.7.0
Mangoni et al., 1997 Rat ventricular myocytesNative L2 mM Ca2+ N.R.3.0
  • N.R., not reported; Room temp., room temperature; CHO, Chinese hamster ovary; DRG, dorsal root ganglion.