Table 3

Effect of bupropion pretreatment on morphine and (−)-epibatidine-induced antinociception after s.c. injection in mice using the tail-flick test

Treatment%MPE ± S.E.
Vehicle/vehicle7  ± 2
Bupropion (10 mg/kg)/vehicle8  ± 2
Vehicle/morphine84  ± 10
Bupropion (10 mg/kg) +morphine78  ± 17
Vehicle-(−)-epibatidine88  ± 7
Bupropion (10 mg/kg) + (−)-epibatidine10  ± 53-a

Mice were pretreated with bupropion (10 mg/kg) 10 min before morphine (7 mg/kg) or (−)-epibatidine (10 μg/kg). Each point represents the mean ± S.E. of 6 to 12 mice.

  • 3-aP < .05 from vehicle/(−)-epibatidine.